Assess the safety and effectiveness of the J-Valve Transfemoral (TF) System in patients with symptomatic, severe, native aortic valve regurgitation (AR) and AR-dominant mixed aortic valve disease, who are judged by a multi-disciplinary heart team to be at high risk for open surgical aortic valve replacement (SAVR). Condition: Symptomatic, severe (grade 3 or 4), native aortic valve regurgitation (AR) and AR-dominant mixed aortic valve disease.

Condition:  Aortic Valve Regurgitation (AR)

Trial ID: J-Valve Transfemoral Pivotal Study (JOURNEY) Testing For: The safety and effectiveness of the J-Valve Transfemoral (TF)