Endometrial Cancer: When Should You See a Doctor?

Endometrial cancer is a cancer of the lining of the uterus, a hollow pear-shaped organ in women in which a fetus can develop. (This lining is known as the endometrium.) Endometrial cancer is the most common cancer of the female reproductive tract, with an estimated 40,000 women diagnosed each year. Fortunately, it has a high cure rate. According to the American Cancer Society, the 5-year survival rate is 88 percent.

Endometrial cancer is not the same as some other less-common malignancies involving the uterus. For example, uterine sarcomas are malignancies arising from the wall of the uterus, not the lining. All in all, these other cancers make up less than 10 percent of the malignant tumors arising from the uterus.

Who has the greatest risk of developing endometrial cancer?

Women who get endometrial cancer tend to share certain characteristics. Having these risk factors doesn’t mean you’ll get the cancer, of course, just as being free of risk factors doesn’t guarantee safety. But you’re more likely to develop this cancer if:

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• You’re over the age of 50. Less than five percent of endometrial cancer cases are diagnosed in women under 40.
• You’re on hormone replacement therapy. Both large doses of estrogen and long-term treatment with it seem to elevate the risk of endometrial cancer. Using both estrogen and progesterone appears to reduce the risk of taking estrogen by itself.
• You’re overweight. If your weight is somewhat above the acceptable range for your height, you’re twice as likely to get endometrial cancer as a woman at a lower weight. If you’re obese, your risk is three to 10 times greater than that of those who aren’t. Scientists believe this is because the more fat cells a woman has, the more estrogen she produces.
• You have diabetes or high blood pressure. Studies show these conditions may increase the risk of endometrial cancer, but scientists aren’t sure whether this is a direct result of the diseases or because people who have these diseases tend to be overweight.
• You’re taking tamoxifen. Using this drug to treat breast cancer raises your risk of developing endometrial cancer, perhaps because it affects the uterus much as estrogen does.
• You’re white. White women are more likely to develop endometrial cancer than women of other races.

Other risk factors include having no biological children, going through menopause late in life, suffering from polycystic ovarian syndrome, and having a history of breast or ovarian cancer. One thing that lowers your risk, according to the American Cancer Society, is having used oral contraceptives containing both estrogen and progesterone, especially over a long period.

What are the symptoms of endometrial cancer?

Bleeding after menopause can be an indication of endometrial cancer. If that happens, you should see your doctor for a checkup as soon as possible. For women who haven’t gone through menopause, bleeding between periods might signal either endometrial or cervical cancer (or other problems, such as vaginal infections). Other symptoms of endometrial cancer include pain during intercourse and painful or difficult urination.

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When should I see my doctor?

Make an appointment promptly if you have any of the following symptoms:

• Unusual discharge or vaginal bleeding
• Difficult or painful urination
• A chronic ache in the pelvic area
• Pain during intercourse

These symptoms often have other causes, but your doctor can make sure your problem isn’t an early sign of endometrial cancer.

How is endometrial cancer diagnosed?

If your doctor suspects you have endometrial cancer, she’ll do a pap smear (take a sample of cells from your cervix to be inspected for abnormalities) and a transvaginal ultrasound (where a probe is inserted into your vagina and sound waves are used to detect tumors). She’ll probably also do a biopsy of your uterine lining, removing a sample of tissue that will be examined for cancerous cells.

If cancer is detected, your doctor will then determine how far it has spread. There are four stages: Stage I means the cancer is confined to the uterus. In stage II, it has spread to the cervix. In stage III, it has spread to other reproductive organs. In stage IV, it’s spread to