If you’re trying to lose weight, you’ve probably asked yourself: “Does cutting calories help lose weight?” For years, the standard advice has been to reduce your daily caloric intake. But a new clinical trial suggests there’s a better way — intermittent fasting, specifically fasting every other day.
Published in the Annals of Internal Medicine (March 31, 2025), this study found that participants following a 4:3 intermittent fasting plan lost more weight and stuck with their diet longer than those who simply reduced their calorie intake.
Let’s explore how this works, why it might outperform traditional dieting, and how you can get started — even if you don’t want to count calories every day.
The 4:3 intermittent fasting method involves:
Fasting for three nonconsecutive days per week
On fasting days, cutting calorie intake by about 80% (typically 400–600 calories)
Eating without restriction on the other four days
This approach alternates fasting and feeding, helping to reduce total weekly intake while avoiding the fatigue of daily calorie restriction.
RELATED: 4 Ways Intermittent Fasting Can Improve Your Health
165 overweight or obese adults
Group 1: 4:3 intermittent fasting
Group 2: Cut calories by 34% daily
All participants were asked to exercise 300 minutes per week (double the national guideline)
Both groups received dietitian-led weight loss coaching
Fasting group lost 8% of body weight
Calorie-cutting group lost 5%
38% of fasters lost ≥10% of their body weight, vs. 16% of calorie cutters
Dropout rate: 19% (fasting) vs. 30% (calorie reduction)
The findings show intermittent fasting not only supports more weight loss but also boosts long-term adherence, which is a huge factor in success.
You might wonder, “If I eat fewer calories every day, why isn’t it working?” The answer could lie in behavior and biology:
You naturally eat less over the week with fasting, but without daily restrictions
Calorie fatigue from tracking every meal leads to burnout
Fasting may improve metabolic flexibility, encouraging the body to burn fat more efficiently
Intermittent fasting may reduce hunger hormones and inflammation
That’s why some people find results faster with a structured plan like this — even those stuck in a “3 weeks calorie deficit, no weight loss” frustration.
RELATED: Thinking About Water Fasting? Here’s 5 Things You Should Know First
Here are some top search queries from people researching intermittent fasting — and the facts behind them:
There’s no clinical evidence linking intermittent fasting to heart attacks. In fact, this study found improvements in:
Blood pressure
Cholesterol
Blood sugar
That said, people with heart conditions should consult their doctor before starting any restrictive eating plan.
Digestive changes like bloating, gas, or constipation can happen during the adjustment period. To minimize issues:
Stay hydrated
Eat high-fiber foods on eating days
Include fermented foods like yogurt or sauerkraut
Yes — rapid eating can lead to overeating, gas, and spikes in blood sugar. Be mindful: chew slowly and eat balanced meals.
Many dieters aim for a 1200-calorie meal plan or try a 1500-calorie-a-day weight loss strategy. While these can create calorie deficits, they often lead to:
Persistent hunger
Fatigue and mood swings
Difficulty sustaining the diet
By contrast, 4:3 intermittent fasting may allow you to eat more freely on non-fasting days, making the process feel less restrictive, and possibly more effective over time.
One major benefit of intermittent fasting is that you don’t have to obsess over every bite. Here’s how you can get started:
Pick three nonconsecutive days (e.g., Monday, Wednesday, Friday). Consistency builds habit.
Aim for 400–600 calories, emphasizing:
Lean protein (chicken, fish, tofu)
Leafy greens and non-starchy veggies
Broth-based soups
Hydration (herbal teas, water)
Don’t overdo it. Stick to:
Complex carbs (quinoa, brown rice)
Healthy fats (avocado, olive oil)
Protein and fiber to keep you full
Aim for 300 minutes of exercise per week — walking, resistance training, swimming, or cycling.
Some foods can make fasting easier and more effective:
Watermelon – low-calorie and hydrating (yes, it’s good for weight loss!)
Eggs – high in protein, low in calories
Greek yogurt – great for digestion and protein
Vegetables – especially leafy greens and cruciferous types
Legumes and beans – good for fiber and satiety
While intermittent fasting can be effective, it’s not suitable for everyone, especially:
People who are underweight or have disordered eating patterns
Pregnant or breastfeeding women
Those with medical conditions requiring regular food intake
For others — especially those frustrated by “weeks of calorie deficit with no weight loss” — it can offer a fresh, more sustainable alternative.
So, does cutting calories help lose weight? Yes — but how you cut them matters.
If daily restrictions feel exhausting, 4:3 intermittent fasting could help you:
Lose weight without counting calories every day
Stay committed long term
See better health improvements
Always talk to your healthcare provider before making major dietary changes, especially if you have underlying conditions.
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