In the past multiple sclerosis (MS) was thought to primarily affect whites. However, studies have shown a higher incidence of MS in the Black community with newly diagnosed cases. Black people who are diagnosed with MS may develop more severe symptoms than other races.
A new study may help explain why people with MS experience worsening disability while those with two related diseases do not.
Blacks may experience different symptoms than people with MS of other races, according to the National Multiple Sclerosis Society:
MS also causes permanent brain and spinal cord scarring.
Researchers investigated whether the same damage accompanies two rarer, similar diseases in which the immune system also attacks the central nervous system.
The diseases are known as aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disorder (MOGAD).
All three illnesses involve inflammation that damages myelin, the insulation around nerves. The body tries to repair the myelin, but the fix may be incomplete and result in scarring.
“The differences in scarring that we found will help physicians distinguish these three diseases more easily to aid in diagnosis,” senior study author Eoin Flanagan says. “More importantly, our findings improve our understanding of the mechanisms of nerve damage in these three diseases and may suggest an important role of such scars in the development of long-term disability in MS.”
The new study included 67 patients with MS; 51 with AQP4-NMOSD; and 38 with MOGAD.
In MS, attacks cause areas of inflammation that shrink only slightly and leave moderately sized scars.
During AQP4-NMOSD attacks, large areas of inflammation occur that commonly leave scars. But those scars tend to be smaller and in less important neurological locations than with MS.
MOGAD patients also have large areas of inflammation during an attack, but scarring is rarer. This suggests that there is a need for an enhanced ability to repair the damaged myelin, according to findings recently published in the journal Neurology.
“Our study highlights the importance of the currently available MS medications that very effectively can prevent attacks, new lesions and subsequent scar formation,” Dr. Elia Sechi, first author, says.
Flanagan says researchers hope that the improved understanding of how MOGAD repairs its lesions may lead to novel ways to prevent scar formation in MS.
There is no cure for MS, but this research will help. The right treatment and medication will also help slow the progression of the disease, relieve symptoms and reduce the number of relapses as well as the severity.
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